| 발표일자: |
2013년 11월 1일(금) ~ 11월 3일(일) |
| 발표번호: |
P(e-poster)-062 |
| 발표장소: |
킨텍스 제2전시장 7B홀 |
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| 자가면역 포도막염 동물 모델에서 인간 골수 유래 중간엽 줄기세포의 효과 |
| 서울대학교 의과대학 안과학교실 |
| 오주연, 김태완 정현정, 이현주, 류진숙, 허장원, 김미금, 위원량 |
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목적 : Mesenchymal stem/stromal cells (MSCs) have the remarkable ability to protect tissues by modulating immune responses in various autoimmune diseases. We here investigated that systemic administration of MSCs might prevent development of experimental autoimmune uveitis (EAU) in mice, a model for human autoimmune uveitis.
방법 : We injected MSCs intraperitoneally in mice immediately after EAU induction, and analyzed draining lymph nodes (DLNs) and retinas.
결과 : Analysis of the retina during the efferent phase revealed that MSCs protected the retina from inflammation-mediated damage and suppressed levels of pro-inflammatory cytokines in the eye. Analysis of DLNs during the afferent phase showed that MSCs decreased the proportions of IL-17+ or IFN-γ+ CD4+ T cells. Levels of IL-1β, IL-6, IL-12, and IL-23 which are involved in Th1/Th17 development were not decreased by hMSCs. However, hMSCs significantly increased the level of immunoregulatory cytokine IL-10, and induced the population of IL-10+B220+CD19+ cells in DLNs.
결론 : Together, data demonstrate that systemic administration of hMSCs attenuates EAU by inducing IL-10-secreting B220+CD19+ cells and by suppressing the Th1/Th17 immune responses.
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