| 발표일자: |
2013년 11월 1일(금) ~ 11월 3일(일) |
| 발표번호: |
P(판넬)-016 |
| 발표장소: |
킨텍스 제2전시장 7B홀 |
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| BIMATOPROST 0.01% IN TREATMENT-NAÏVE OPEN-ANGLE GLAUCOMA PATIENTS IN THE KOREAN CLINICAL SETTING |
| Seoul National University Hospital(1), Allergan Singapore Pte Ltd(2), Severance Hospital(3), Kim's Eye Hospital(4), Asan Medical Center(5) |
| Ki Ho Park(1), Susan Simonyi(2), Chan Yun Kim(3), Yong Ho Sohn(4), Michael Scott Kook(5) |
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Purpose : Purpose:
To evaluate the effect of bimatoprost 0.01% in naive to treatment subjects with open-angle glaucoma (OAG) who have low intraocular pressures (IOP) at baseline in the Korean clinical setting.
Methods : Methods:
In this study there were 295 OAG or ocular hypertensive patients naive to IOP lowering treatments that were treated with bimatoprost 0.01% and observed at week 6 and week 12. IOP evaluations were grouped by baseline (BL) IOP >21 or ≤21 mmHg. Hyperemia was measured by a masked evaluator using a photonumeric grading scale (0, +0.5, +1, +2, +3). Hyperemia was grouped as (0 to +1) and (+2 to +3). Shifts between groupings were reported as no change, improved (+2 to +3) to (0 to +1) or worsened (0 to +1) to (+2 to +3).
Results : Results:
There were 73 patients who had a BL IOP > 21 mmHg with a mean IOP of 25.7±5.0 mmHg while 222 patients had a BL IOP ≤ 21 mmHg with a mean IOP of 16.3±3.0 mmHg. Following initiation of bimatoprost 0.01% treatment, mean IOPs at week 6 and week 12 respectively were reduced to 16.4 ±4.0 mmHg; -34.5% (p<0.0001) and 16.7 ±3.9; -32.0% (p<0.001) mmHg in the BL IOP >21 mmHg group, and 13.3 ± 2.6; -17.8% (p<0.001) and 13.7 ± 2.8;-15.9% (p<0.001) in the BL IOP ≤ 21 group. Hyperemia shifts from baseline at week 6 and week 12 reported as no change, improved and worsened were 86.9% and 86.8%, 0.8% and 0.5%, and 12.4% and 12.7%, respectively.
Conclusion : Conclusion:
Bimatoprost 0.01% significantly reduced IOP, regardless of baseline in naive to treatment patients with low shifts in hyperemia.
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