| 목적 : To compare the diagnostic sensitivities of the time-domain optical coherence tomography (TD-OCT; Stratus OCT) and the spectral-domain optical coherence tomography (SD-OCT; Spectralis OCT) to detect retinal nerve fiber layer (RNFL) defects using a built-in normative database in patients with glaucoma.방법 : Fifty-two eyes of 35 glaucoma patients with photographically identified RNFL defects were included in this cross-sectional study. As the RNFL defects presenting in both superior and inferior hemiretina were considered separately, a total of 69 hemiretina were analyzed in the study. Both the fast RNFL scan of Stratus OCT and the single circle scan of Spectralis OCT were taken from all subjects. Based on the level of statistical significance compared with the built-in normative database, the sensitivities of parameters for detecting RNFL defects were calculated and compared between 2 devices.결과 : The Spectralis OCT found RNFL defects more frequently than the Stratus OCT when using the quadrant sector parameter abnormal at the 5% (79.7% vs 63.8%) and 1% level (56.5% vs 40.6%) (all P = 0.01). The sensitivity of the Spectralis OCT was higher than that of Stratus OCT with borderline significance when comparing the clock-hour parameter of Stratus OCT with the 6 standard sector parameter of Spectralis OCT abnormal at the 5% level (82.6% vs 72.5%, P = 0.09), and significantly higher at the 1% level (68.1% vs 39.1%, P < 0.01).결론 : The parameters of both Stratus and Spectralis OCT showed only moderate sensitivities to detect glaucomatous RNFL defect when using their built-in normative database. However, most of Spectralis OCT parameters had better ability than Stratus OCT parameters. Among the various parameters of both devices, the 6 standard sector parameter of Spectralis OCT abnormal at the 5% level appeared to be the most sensitive in the detection of glaucomatous RNFL defects. |