목적 : To determine the intraocular distribution of oxygen tension (pO2) and temperature in various retinal diseases: diabetic retinopathy, rhegmatogenous retinal detachment, and epiretinal membrane.
방법 : The pO2 and temperatures were measured before vitrectomy at sites in the mid-anterior chamber (AC), in the anterior chamber angle, in the mid-vitrous cavity, and at the inner retina surface using an fiber-optic oxygen/temperature sensor (Oxylab pO2 Optode) in 8 subjects with PDR who had developed recurrent vitreous hemorrhage, 17 subjects with rhegmatogenous retinal detachment (RRD), and 19 subjects with epiretinal membrane (ERM). In addition, 9 subjects with intravitreal silicone oil and 4 subjects with pseudophakia were included in this study.
결과 : The mean pO2 in mid-vitreous in PDR(16.99 ± 8.22 mmHg) was significantly higher than those in ERM(6.66 ± 3.39 mmHg)(P=. 027). The mean pO2 in mid-AC and at inner retina surface in RRD were 13.77 ± 5.95 and 4.81 ± 2.95 mmHg, which were significantly different from those in ERM(5.30 ± 4.46 and 10.24 ± 3.18 mmHg; P=.037 and .001). The mean pO2 in mid-vitreous and inner retina surface in silicone oil filled eyes were 8.63 ± 2.45 and 8.76 ± 2.37 mmHg, which were not significantly different from those in ERM(P=.052 and .493). 결론 : We identified significant high intraocular pO2 especially in mid-vitreous in PDR with recurrent vitreous hemorrhage. Although our findings are not consistent with the previous reports that the intravitreal pO2 in PDR was lower than control, we suggest that recurrent vitreous hemorrhage and elevated VEGF would induce the massive neovascular complexs in the retina and then paradoxically increase PO2. In addition, the pO2 in the silicone filled eye was not different from control in this study and we confirmed significant intraocular temperature gradient in the various retinal diseases. |