| 목적 : To demonstrate in vivo assessment of plasmin-induced posterior vitreous detachment (PVD) and vitreous liquefaction in a rabbit model using the Digital Fluoroscopy System (DFS).방법 : Twenty eyes of 10 New Zealand white rabbits were divided into five groups. In each group, one rabbit received an intravitreal injection of 2.0 U plasmin in the right eye and 0.5 U plasmin in the left eye. Intravitreal injection of 0.1 ml balanced salt solution (BSS) was performed in the right eye and no injection was performed in the left eye of the other rabbit taken as a control. Intraocular fluid dynamics was assessed by the DFS (AXIOM Artis dFC, Siemens, USA) with a contrast agent in each group at different time intervals (6, 12 hours, 1, 3, and 7 days).결과 : Complete PVD was observed after 12 hours with 2.0 U plasmin injection, while complete PVD was observed only after 3 days with 0.5 U plasmin injection. The eyes with BSS injection or without injection failed to show complete PVD even after 7 days. Complete vitreous liquefaction was observed after 7 days with 2.0 U plasmin injection, but no eyes with 0.5 U plasmin or BSS injection showed complete liquefaction. We could confirm clearly the presence of PVD and the degree of vitreous liquefaction by using the DFS.결론 : The DFS is a useful tool for the evaluation of pharmacologic vitreolysis considering clear visualization of vitreous liquefaction. The different status of PVD and vitreous liquefaction could be observed after different dose and elapsed time of injection of plasmin. |