| 대한안과학회 제109회 학술대회 발표 연제 초록 |
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| Granulocyte Colony-Stimulating Factor (G-CSF) accelerates the development of neovascular glaucoma in patient with proliferative diabetic retinopathy | |||||||||
| 한양대학교 의과대학 안과학교실 Department of Ophthalmology, Hanyang University College of Medicine | |||||||||
| Hee Yoon Cho, Mincheol Sung, Min Ho Kang | |||||||||
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목적 : The study aimed to compare the concentration of intraocular cytokines in aqueous humor samples from patients with neovascular glaucoma(NVG) due to proliferative diabetic retinopathy (PDR). 방법 : The authors collected aqueous samples from 6 eyes of 6 patients with NVG secondary to PDR and 6 eyes of 6 patients with PDR without iris neovascularization(NVI). The aqueous humor levels of vascular endothelial growth factor (VEGF) and 10 common families of interleukins, Interferon-gamma (IFN-g) , tumor necrosis factor (TNF)-α, and Granulocyte colony stimulating factor (G-CSF) were measured using suspension array technology. 결과 : The VEGF level and G-CSF level in patients with NVG were significantly higher than those in patients with PDR without NVI (p = .023 and .048, respectively). The mean concentration of G-CSF in aqueous humor of patients with NVG(87.6±83.3 ng/ml) was 8.7-fold higher than that of patients with only PDR(10.0±13.4 ng/ml) . 결론 : The author’s findings show that patients with NVG secondary to PDR had a significantly 8.7-fold higher level of G-CSF than that in patients with only PDR. Although the level of VEGF was also higher, the great upregulation of G-CSF might implicate G-CSF as an important factor in the pathogenesis of NVG secondary to PDR. |
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