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목적 : To evaluate changes in neural retina (NR) thickness and photoreceptor integrity induced by photodynamic therapy (PDT) for the treatment of chronic central serous chorioretinopathy (CSC).
방법 : This retrospective study included 8 eyes (8 patients, group I) with non-chronic CSC and 7 eyes (7 patients, group II) with chronic CSC treated by intravitreal bevacizumab as control groups, and 16 eyes (16 patients, group III) with chronic CSC treated by half-fluence PDT as a case group. LogMAR best corrected visual acuity and spectral domain optical coherence tomography were evaluated at each visit during 6 months follow-up.
결과 : NR thickness in group II and group III was significantly thinner than group I at baseline and 6 month. However, there was no difference between group II and group III at baseline and 6 month (p=0.303, p=0.254, respectively). The proportion of eyes with intact inner segment/outer segment junction (IS/OS) and cone outer segment tips (COST) lines increased in each group during follow-up. Group II and group III showed significantly more eyes with the intact IS/OS and COST lines than group I at 6 month, whereas no difference was found between group II and group III at 6 month.
결론 : Our findings show that the use of half-fluence PDT does not induce NR change in addition to the thinning caused by chronic evolution of the disease. Spontaneous resolution of acute CSC also showed significant NR thinning.
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