| 발표일자: |
2013년 4월 20일(토) ~ 21일(일) |
| 발표시간: |
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| 발표번호: |
P(e-poster)-080 |
| 발표장소: |
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| Predictors for the progression of geographic atrophy in patient with age-related macular degeneration : fundus autofluorescence study with modified fundus camera |
| Department of Ophthalmology, Kangdong Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea |
| Yong Jin Jeong, In Hwan Hong, Yoon Jae Wi, Ha Bum Lee, Sung Pyo Park |
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목적 : We aimed to determine the association between abnormal fundus autofluorescence (FAF) features on images obtained from a modified fundus camera (mFC) and the progression of geographic atrophy (GA) in patients with age-related macular degeneration (AMD).
방법 : Consecutive serial FAF images of 86 eyes from 86 patients with GA were enrolled. All FAF images were obtained with an mFC. The area of GA (mm2) was quantified at baseline and at 1-year follow-up using customized segmentation program and the rate of GA enlargement during a year was calculated. Patterns of abnormal FAF in the junctional zone were classified into None or minimal change, Focal, Patchy, Banded, and Diffuse according to published classification system. Logistic regression analysis was used to evaluate the relationship between GA enlargement and abnormal FAF.
결과 : The mean rate of GA enlargement for the None or minimal change, Focal, Banded, Patchy and Diffuse pattern of abnormal FAF was 0.20, 0.53, 1.69, 1.16 and 1.74 mm2 per year, respectively. Binary logistic regression analysis revealed the Banded (odds ratio [OR] = 8.33; p = 0.01) and the Diffuse pattern (OR = 4.62; p = 0.04) of abnormal FAF had significantly high risk for GA enlargement compared to the None or minimal change pattern. The pooled data of the Banded and Diffuse patterns of abnormal FAF had higher risk for GA enlargement (OR = 3.18; p = 0.01) than the pooled data of other patterns.
결론 : FAF image acquisition by mFC appears to be adaptable for evaluation in accordance with published cSLO-based classification system. Based on these classification system, the Banded or Diffuse FAF patterns on baseline FAF images indicate a higher risk of GA progression than other patterns in patients with AMD. The identification of high-risk characteristics with mFC is a broadly available method that will provide additional information for predicting the disease course.
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