| 발표일자: |
2012년 11월 02일 (금) |
| 발표시간: |
14:19~14:26 |
| 발표번호: |
녹F-08 |
| 발표장소: |
A방 |
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| 7.0-Tesla MRI를 이용한 개방각 녹내장 환자에서의 가쪽무릎핵 위축에 대한 평가 |
| 가천대학교 길병원 안과학 교실¹
가천대학교 뇌과학연구소²
고려대학교 의과대학 안과학 교실³ |
| 이종환¹, 정혜진², 최상한², 김영보², 조장희², 김용연³, 이종연¹ |
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목적 : Glaucoma is characterized by progressive degeneration of retinal ganglion cells (RGC) and their axons. Recent neuroimaging studies in human glaucoma have demonstrated degenerative changes in the visual pathway of brain including lateral geniculate nucleus (LGN). However, a precise assessment of the LGN is still a technical challenge due to anatomic characteristics. Therefore, our aim was to investigate the LGN atrophy in patients with open-angle glaucoma using high-resolution 7.0 Tesla MR imaging and correlation with retinal nerve fiber layer (RNFL) thickness.
방법 : 15 patients with open-angle glaucoma and 15 age-matched controls were included in this study. Following adjustment of MRI parameter to obtain optimum image of LGN, all subjects underwent 7.0-Tesla MRI. Coronal proton density weighted magnetic resonance images of both LGNs were obtained, and LGN height was measured by 2 blinded experimenters. Measurements were compared between two groups and correlation between LGN height and RNFL thickness with optical coherence tomography was analyzed.
결과 : Both LGNs were clearly identified with 7.0 Tesla MRI for every subject. Compared with controls, the mean LGN height in glaucoma were decreased in right (4.22 ± 0.54 mm vs 4.60 ± 0.55 mm, p=0.041) and left (4.28 ± 0.47 mm vs 4.74 ± 0.68 mm, p=0.030) LGNs. The combined right and left LGN height in glaucoma was also significantly decreased compared with controls (8.50 ± 0.89 mm vs 9.35 ± 1.19 mm, p=0.042). The LGN height was significantly correlated with total RNFL thickness (p=0.011).
결론 : The present study confirmed the LGN atrophy in OAG patients with high resonance imaging with 7.0 Tesla MRI. The finding that LGN height was correlated with RNFL thickness more strongly suggests that a process called transsynaptic degeneration is involved in glaucoma.
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